[KO Validated] PTPN1 Rabbit Polyclonal Antibody (CAB1590)
- SKU:
- CAB1590
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | [KO Validated] PTPN1 Rabbit Polyclonal Antibody |
SKU: | CAB1590 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 281-435 of human PTPN1 (NP_002818.1). |
Sequence: | IMGD SSVQ DQWK ELSH EDLE PPPE HIPP PPRP PKRI LEPH NGKC REFF PNHQ WVKE ETQE DKDC PIKE EKGS PLNA APYG IESM SQDT EVRS RVVG GSLR GAQA ASPA KGEP SLPE KDED HALS YWKP FLVN MCVA TVLT AGAY LCYR FLFN SNT |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | PTP1B; PTPN1 |
Positive Sample: | BT-474,SKOV3,U-251MG,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasmic side, Endoplasmic reticulum membrane, Peripheral membrane protein. |
Calculated MW: | 50kDa |
Observed MW: | 50kDa |
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5770 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |