The Phospho-PTK2 (Y925) Polyclonal Antibody (CABP0599) is a valuable tool for researchers studying PTK2, a protein tyrosine kinase involved in cell adhesion and migration processes. This antibody, raised in rabbits, is highly specific for the phosphorylated form of PTK2 at tyrosine 925 and is validated for use in Western blot applications. It allows for the detection and analysis of phosphorylated PTK2 in various cell types, making it ideal for studies in cell biology, cancer research, and signal transduction pathways.PTK2 is a key player in cellular processes such as cell spreading, migration, and proliferation, making it a critical target for research in cancer metastasis and invasion.
The phosphorylation of PTK2 at tyrosine 925 is known to be important for its activation and downstream signaling pathways, further highlighting the significance of this antibody in understanding PTK2-mediated cellular functions.This antibody provides researchers with a powerful tool to investigate the role of phosphorylated PTK2 in various physiological and pathological conditions, ultimately contributing to the development of targeted therapies for diseases involving dysregulated PTK2 signaling pathways.
Product Name:
Phospho-FAK-Y925 Rabbit Polyclonal Antibody
SKU:
CABP0599
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic phosphorylated peptide around Y925 of human FAK (NP_722560.1).
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5747
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Jurkat cell line, using Phospho-FAK-Y925 antibody (CABP0599) 1:1000 dilution..Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
