The Presenilin-2 Polyclonal Antibody (CAB7719) is a vital tool for researchers studying Presenilin-2, a protein involved in the processing of amyloid precursor protein and the pathogenesis of Alzheimer's disease. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot analysis. By targeting the Presenilin-2 protein, this antibody enables precise detection and characterization of this key player in neurodegenerative disorders.Presenilin-2 is a crucial component of the γ-secretase complex, responsible for cleaving amyloid precursor protein into amyloid-beta peptides implicated in Alzheimer's disease development.
Research into the role of Presenilin-2 in this process is essential for understanding the molecular mechanisms underlying neurodegeneration and identifying potential therapeutic targets. The Presenilin-2 Polyclonal Antibody is a valuable tool for investigating the functions and dysregulation of this protein in Alzheimer's disease pathology and may lead to new insights in drug development efforts targeting this devastating condition.
Product Name:
PSEN2 Rabbit Polyclonal Antibody
SKU:
CAB7719
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 267-384 of human PSEN2 (NP_000438.2).
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
Purification Method:
Affinity purification
Gene ID:
5664
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PSEN2 antibody (CAB7719) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
