The Phospho-PRKDC (S2056) Polyclonal Antibody (CABP0621) is a key tool for researchers studying the DNA-dependent protein kinase catalytic subunit (PRKDC) and its phosphorylation at serine 2056. PRKDC is a critical player in DNA damage response and repair processes, making it a crucial target for cancer research and therapy development.This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting phosphorylation at S2056 of PRKDC in human samples. It has been rigorously validated for use in Western blot applications, allowing researchers to accurately assess PRKDC phosphorylation levels in various cell types and conditions.
The phosphorylation of PRKDC at S2056 is known to impact its kinase activity and function in DNA repair pathways, making it a key marker for assessing DNA damage and repair processes. By utilizing this antibody, researchers can gain valuable insights into the role of PRKDC phosphorylation in cancer development, treatment response, and resistance mechanisms.Overall, the Phospho-PRKDC (S2056) Polyclonal Antibody (CABP0621) is an essential tool for investigating the functions of PRKDC in DNA damage response pathways and its potential as a therapeutic target in cancer treatment strategies.
Product Name:
Phospho-PRKDC-S2056 Rabbit Polyclonal Antibody
SKU:
CABP0621
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic phosphorylated peptide around S2056 of human DNA-PKcs (NP_008835.5).
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.
Purification Method:
Affinity purification
Gene ID:
5591
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using Phospho-DNA-PKcs-S2056 Rabbit pAb (CABP0621).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
