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Phospho-PRKACA/PRKACB/PRKACG (T198) Antibody (PACO04707)

SKU:
PACO04707
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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Phospho-PRKACA/PRKACB/PRKACG (T198) Antibody (PACO04707)

The Phospho-PRKACA/PRKACB/PRKACG (T198) Antibody (PAC04707) is a valuable tool for researchers studying protein kinase A (PKA) signaling pathways. This antibody, produced in rabbits, specifically recognizes the phosphorylated form of PRKACA, PRKACB, and PRKACG at threonine 198. It has been validated for use in Western blot applications and is highly reactive with human samples.PRKACA, PRKACB, and PRKACG are key regulatory subunits of PKA, an enzyme that plays a crucial role in various cellular processes such as gene expression, metabolism, and cell growth. The phosphorylation of these subunits at threonine 198 is known to regulate the activity of PKA and its downstream signaling pathways.

Researchers studying signal transduction, cell signaling, and protein phosphorylation will find this antibody particularly useful in their studies. By detecting the phosphorylated form of PRKACA, PRKACB, and PRKACG, researchers can investigate the role of PKA signaling in physiological and pathological conditions, including cancer, cardiovascular diseases, and neurological disorders. This antibody is a valuable tool for understanding the complex regulatory mechanisms of PKA and its implications in human health and disease.

Antibody Name:Phospho-PRKACA/PRKACB/PRKACG (T198) Antibody
Antibody SKU:PACO04707
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from human PKAalpha/Beta/gamma cat around the phosphorylation site of T198.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:PRKACA; PKACA; cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha; PRKACB; cAMP-dependent protein kinase catalytic subunit beta; PKA C-beta; PRKACG; cAMP-dependent protein kinase catalytic subunit gamma; PKA C-gamma
UniProt Protein Function:PKACA: catalytic subunit of cAMP-dependent protein kinase alpha, an AGC kinase. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Two splice-variant isoforms have been described.
UniProt Protein Details:

Protein type:Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.11; AGC group; PKA family

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: centrosome; membrane; mitochondrion; plasma membrane; cytosol; nucleus; neuromuscular junction; AMP-activated protein kinase complex; cAMP-dependent protein kinase complex

Molecular Function:protein binding; cAMP-dependent protein kinase activity; ubiquitin protein ligase binding; protein serine/threonine/tyrosine kinase activity; protein kinase binding; ATP binding

Biological Process: nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; water transport; pathogenesis; signal transduction; protein amino acid phosphorylation; positive regulation of protein export from nucleus; triacylglycerol catabolic process; G2/M transition of mitotic cell cycle; transmembrane transport; sperm capacitation; regulation of synaptic transmission; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; cytosolic calcium ion homeostasis; regulation of osteoblast differentiation; regulation of heart rate; organelle organization and biogenesis; activation of protein kinase A; peptidyl-threonine phosphorylation; glucose metabolic process; gluconeogenesis; peptidyl-serine phosphorylation; mesoderm formation; phospholipase C activation; regulation of protein binding; neural tube closure; carbohydrate metabolic process; energy reserve metabolic process; innate immune response; renal water homeostasis; mitotic cell cycle; blood coagulation; regulation of insulin secretion

NCBI Summary:cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
UniProt Code:P17612
NCBI GenInfo Identifier:125205
NCBI Gene ID:5566
NCBI Accession:P17612.2
UniProt Secondary Accession:P17612,Q32P54, Q9H2Y0, Q9NRB4, Q9NRH9,
UniProt Related Accession:P17612
Molecular Weight:39,953 Da
NCBI Full Name:cAMP-dependent protein kinase catalytic subunit alpha
NCBI Synonym Full Names:protein kinase, cAMP-dependent, catalytic, alpha
NCBI Official Symbol:PRKACA  
NCBI Official Synonym Symbols:PKACA  
NCBI Protein Information:cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha; protein kinase A catalytic subunit; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1
UniProt Protein Name:cAMP-dependent protein kinase catalytic subunit alpha
Protein Family:cAMP-dependent protein kinase
UniProt Gene Name:PRKACA  
UniProt Entry Name:KAPCA_HUMAN

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