Phospho-PPP1R2 (S44) Antibody (PACO04673)
- SKU:
- PACO04673
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Phospho-PPP1R2 (S44) Antibody (PACO04673)
The Phospho-PPP1R2 (S44) Polyclonal Antibody (PACO04673) is a valuable tool for researchers studying PPP1R2, a protein involved in cell cycle regulation and cell division. This antibody, raised in rabbits, has high specificity and sensitivity for detecting phosphorylation of PPP1R2 at serine 44 in human samples. It is validated for use in Western blot applications, allowing for the identification and quantification of phosphorylated PPP1R2 in various cell types.PPP1R2 is a key regulator of protein phosphatase 1 (PP1), controlling its activity in the cell cycle and DNA repair processes. Phosphorylation at serine 44 is known to modulate the function of PPP1R2, influencing cell proliferation and DNA damage response pathways.
Research on PPP1R2 phosphorylation is important for understanding its role in cancer development, as dysregulation of the PP1 pathway is linked to tumorigenesis and tumor progression.This antibody provides a reliable tool for investigating the phosphorylation status of PPP1R2, offering insights into its function in cell cycle control and DNA repair mechanisms. By studying the impact of PPP1R2 phosphorylation on cellular processes, researchers can gain a better understanding of its potential as a therapeutic target in cancer treatment and other diseases related to cell division dysregulation.
| Antibody Name: | Phospho-PPP1R2 (S44) Antibody |
| Antibody SKU: | PACO04673 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from human IPP-2 around the phosphorylation site of S44. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | PPP1R2; IPP2; Protein phosphatase inhibitor 2; IPP-2 |
| UniProt Protein Function: | PPP1R2: a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. Two alternatively-spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Inhibitor Chromosomal Location of Human Ortholog: 3q29 Cellular Component: protein phosphatase type 1 complex Molecular Function:protein binding; type 1 serine/threonine specific protein phosphatase inhibitor activity Biological Process: generation of precursor metabolites and energy; regulation of phosphoprotein phosphatase activity |
| NCBI Summary: | Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] |
| UniProt Code: | P41236 |
| NCBI GenInfo Identifier: | 729856 |
| NCBI Gene ID: | 5504 |
| NCBI Accession: | P41236.2 |
| UniProt Related Accession: | P41236 |
| Molecular Weight: | 23,015 Da |
| NCBI Full Name: | Protein phosphatase inhibitor 2 |
| NCBI Synonym Full Names: | protein phosphatase 1 regulatory inhibitor subunit 2 |
| NCBI Official Symbol: | PPP1R2 |
| NCBI Official Synonym Symbols: | IPP2; IPP-2 |
| NCBI Protein Information: | protein phosphatase inhibitor 2 |
| UniProt Protein Name: | Protein phosphatase inhibitor 2 |
| Protein Family: | Protein phosphatase inhibitor |
| UniProt Gene Name: | PPP1R2 |
| UniProt Entry Name: | IPP2_HUMAN |
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