Phospho-PPP1R2 (S120/S121) Antibody (PACO04674)
- SKU:
- PACO04674
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Phospho-PPP1R2 (S120/S121) Antibody (PACO04674)
The Phospho-PPP1R2 (S120/S121) Antibody (PACO04674) is a valuable tool for researchers studying protein phosphatase 1 regulatory subunit 2 (PPP1R2) phosphorylation at serine 120 and 121. This rabbit polyclonal antibody is highly specific and reactive with human samples, making it ideal for Western blot applications.PPP1R2 is a key regulatory subunit of protein phosphatase 1 (PP1), which plays a vital role in the dephosphorylation of target proteins involved in cell cycle progression and signal transduction. Phosphorylation of PPP1R2 at serine 120 and 121 is known to impact its interaction with PP1 and modulate its activity, making it a crucial signaling event in cellular processes.
Researchers in the fields of cell biology, signal transduction, and cancer research can benefit from the use of this antibody to investigate the phosphorylation status of PPP1R2 and its implications on PP1 activity. Understanding the molecular mechanisms underlying PPP1R2 phosphorylation can provide insights into potential therapeutic targets for diseases associated with dysregulated cell signaling pathways.
| Antibody Name: | Phospho-PPP1R2 (S120/S121) Antibody |
| Antibody SKU: | PACO04674 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from human IPP-2 around the phosphorylation site of S120/S121. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | PPP1R2; IPP2; Protein phosphatase inhibitor 2; IPP-2 |
| UniProt Protein Function: | PPP1R2: a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. Two alternatively-spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Inhibitor Chromosomal Location of Human Ortholog: 3q29 Cellular Component: protein phosphatase type 1 complex Molecular Function:protein binding; type 1 serine/threonine specific protein phosphatase inhibitor activity Biological Process: generation of precursor metabolites and energy; regulation of phosphoprotein phosphatase activity |
| NCBI Summary: | Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] |
| UniProt Code: | P41236 |
| NCBI GenInfo Identifier: | 729856 |
| NCBI Gene ID: | 5504 |
| NCBI Accession: | P41236.2 |
| UniProt Related Accession: | P41236 |
| Molecular Weight: | 23,015 Da |
| NCBI Full Name: | Protein phosphatase inhibitor 2 |
| NCBI Synonym Full Names: | protein phosphatase 1 regulatory inhibitor subunit 2 |
| NCBI Official Symbol: | PPP1R2Â Â |
| NCBI Official Synonym Symbols: | IPP2; IPP-2Â Â |
| NCBI Protein Information: | protein phosphatase inhibitor 2 |
| UniProt Protein Name: | Protein phosphatase inhibitor 2 |
| Protein Family: | Protein phosphatase inhibitor |
| UniProt Gene Name: | PPP1R2Â Â |
| UniProt Entry Name: | IPP2_HUMAN |
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