The Phospho-Polr2a (S2) Rabbit Monoclonal Antibody (CABP0996) is a highly specific and sensitive tool for studying the phosphorylation of Polr2a at serine 2 in various research applications. This antibody is raised in rabbits and has been validated for use in Western blotting, immunoprecipitation, and immunofluorescence assays. Polr2a, also known as RNA polymerase II, is a key enzyme involved in the transcription of protein-coding genes. Phosphorylation at serine 2 of Polr2a plays a crucial role in regulating transcription elongation and mRNA processing.
Dysregulation of Polr2a phosphorylation has been implicated in various diseases, including cancer and neurological disorders.The Phospho-Polr2a (S2) Rabbit Monoclonal Antibody (CABP0996) offers researchers a reliable tool for studying the phosphorylation status of Polr2a and its functional implications in cellular processes. Its high specificity and sensitivity make it an essential reagent for studies in molecular biology, biochemistry, and cancer research. Unlock the potential of your research with this advanced antibody.
Product Name:
Phospho-POLR2A-S2 Rabbit Monoclonal Antibody
SKU:
CABP0996
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A phospho specific peptide corresponding to residues surrounding S2 of human POLR2A CTD repeat YSPTSPS.
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
Purification Method:
Affinity purification
Gene ID:
5430
Clone Number:
ARC1540
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Chromatin immunoprecipitations were performed with cross-linked chromatin from 293F cells and Phospho-POLR2A-S2 (CABP0996). The ChIP sequencing results indicate the enrichment pattern of Phospho-POLR2A-S2 in selected genomic region and representative gene loci (GAPDH), as shown in figure.
