PLC gamma 2 (PLCG2) Rabbit Polyclonal Antibody (CAB2182)
- SKU:
- CAB2182
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | PLC gamma 2 (PLCG2) Rabbit Polyclonal Antibody |
SKU: | CAB2182 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PLC gamma 2 (PLC gamma 2 (PLCG2)) (NP_002652.2). |
Sequence: | MSTT VNVD SLAE YEKS QIKR ALEL GTVM TVFS FRKS TPER RTVQ VIME TRQV AWSK TADK IEGF LDIM EIKE IRPG KNSK DFER AKAV RQKE DCCF TILY GTQF VLST LSLA ADSK EDAV NWLS GLKI LHQE AMNA STPT IIES WLRK QIYS VDQT RRNS ISLR ELKT ILPL INFK VSSA KFLK DKFV EIGA HKDE LSFE QFHL FYKK LMFE QQKS ILDE FKKD SSVF ILGN TDRP DASA VYLH DFQR FLIH EQQE HWAQ DLNK VRER MTKF IDDT MRET AEPF LFVD EFLT YLFS RENS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:20 - 1:100 |
Synonyms: | FCAS3; APLAID; PLC-IV; PLC-gamma-2; PLC gamma 2 (PLCG2) |
Positive Sample: | U-251MG,Raji,Ramos |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, extracellular exosome, perinuclear region of cytoplasm, plasma membrane, ruffle membrane |
Calculated MW: | 148kDa |
Observed MW: | 175kDa |
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.
Purification Method: | Affinity purification |
Gene ID: | 5336 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |