Phospho-PLC gamma 1 (PLCG1)-Y783 Monoclonal Antibody (CABP1340)
- SKU:
- CABP1340
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Frequently bought together:
Description
Product Name: | Phospho-PLC gamma 1 (PLCG1)-Y783 Monoclonal Antibody |
SKU: | CABP1340 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | A synthetic phosphorylated peptide around Y783 of human Phospho-PLC gamma 1 (PLCG1)-Y783 (NP_877963.1). |
Sequence: | GFYV E |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 |
Synonyms: | PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1; Phospho-PLC gamma 1 (PLCG1)-Y783 |
Positive Sample: | NIH/3T3 |
Conjugate: | Unconjugated |
Cellular Localization: | cell projection, cytoplasm, cytosol, plasma membrane, ruffle membrane |
Calculated MW: | 149kDa |
Observed MW: | 155kDa |
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5335 |
Clone Number: | ARC54936 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |