Anti-Phospho-PFKFB2-S483 pAb Antibody (CABP0784)
- SKU:
- CABP0784
- Product Type:
- Antibody
- Applications:
- WB
- IP
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Antibody Name: | Anti-Phospho-PFKFB2-S483 Antibody |
Antibody SKU: | CABP0784 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | A synthetic phosphorylated peptide around S483 of human PFKFB2 (NP_006203.2). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human |
Positive Samples: | HeLa |
Immunogen: | A synthetic phosphorylated peptide around S483 of human PFKFB2 (NP_006203.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | NYSV G |
Gene ID: | 5208 |
Uniprot: | O60825 |
Cellular Location: | |
Calculated MW: | 54kDa/58kDa |
Observed MW: | 55KDa |
Synonyms: | PFKFB2, PFK-2/FBPase-2 |
Background: | The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2, 6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2, 6-bisphosphate, and a fructose-2, 6-biphosphatase activity that catalyzes the degradation of fructose-2, 6-bisphosphate. This protein regulates fructose-2, 6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2, 6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. |
UniProt Protein Function: | PFKFB2: a bifunctional heterodimeric enzyme involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. Regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. Two splice-variant isoforms have been described. |
UniProt Protein Details: | Protein type:EC 3.1.3.46; Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; Kinase, other; Phosphatase (non-protein); Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1q31 Cellular Component: cytosol Molecular Function:6-phosphofructo-2-kinase activity; protein binding; protein kinase binding Biological Process: glycolysis |
NCBI Summary: | The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O60825 |
NCBI GenInfo Identifier: | 12643333 |
NCBI Gene ID: | 5208 |
NCBI Accession: | O60825.2 |
UniProt Secondary Accession: | O60825,O60824, Q5VVQ3, Q5VVQ4, Q9H3P1, |
UniProt Related Accession: | O60825 |
Molecular Weight: | 54,406 Da |
NCBI Full Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 |
NCBI Synonym Full Names: | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 |
NCBI Official Symbol: | PFKFB2Â Â |
NCBI Official Synonym Symbols: | PFK-2/FBPase-2Â Â |
NCBI Protein Information: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 |
UniProt Protein Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 |
UniProt Synonym Protein Names: | 6PF-2-K/Fru-2,6-P2ase heart-type isozymeIncluding the following 2 domains:6-phosphofructo-2-kinase (EC:2.7.1.105)Fructose-2,6-bisphosphatase (EC:3.1.3.46) |
Protein Family: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase |
UniProt Gene Name: | PFKFB2Â Â |
UniProt Entry Name: | F262_HUMAN |