The Phospho-PDGFRA (Y1018) Polyclonal Antibody (CABP0615) is a valuable tool for researchers studying the phosphorylated form of the PDGFRA protein, a receptor involved in cell growth and proliferation. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By targeting the phosphorylated tyrosine 1018 residue of the PDGFRA protein, this antibody enables precise detection and analysis of PDGFRA activation in various cell types.PDGFRA is a key player in signaling pathways that control cell growth and differentiation, making it a crucial target for studies in cancer research and developmental biology.
Phosphorylation of specific tyrosine residues, such as Y1018, is known to regulate PDGFRA function and downstream signaling cascades. Understanding the phosphorylation status of PDGFRA can provide insights into its role in various physiological and pathological processes.This Phospho-PDGFRA (Y1018) Polyclonal Antibody is a valuable tool for investigating the activation state of PDGFRA and its implications in cancer progression, tissue regeneration, and other cellular processes. Its high specificity and sensitivity make it a reliable choice for researchers seeking to delve deeper into the molecular mechanisms involving the PDGFRA receptor.
Product Name:
Phospho-PDGFRA-Y1018 Rabbit Polyclonal Antibody
SKU:
CABP0615
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic phosphorylated peptide around Y1018 of human PDGFRA (NP_006197.1).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
123kDa
Observed MW:
200kDa
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
Purification Method:
Affinity purification
Gene ID:
5156
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using Phospho-PDGFR alpha-Y1018 Rabbit pAb (CABP0615) at 1:1000 dilution. HepG2 cells were treated by UV for 15-30 minutes or treated by EGF (100ng/mL) for 30 minutes after serum-starvation overnight.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
