The Phospho-p90RSK (T359/S363) Polyclonal Antibody (CABP0539) is a specialized antibody designed for research involving the phosphorylation of p90RSK at threonine 359 and serine 363. This phosphorylation event is crucial for the activation and regulation of p90RSK, a key signaling protein involved in cell growth, survival, and proliferation.Raised in rabbits, this antibody is highly specific and sensitive for detecting phosphorylated p90RSK in human samples. It has been validated for use in Western blot applications, allowing for precise analysis of p90RSK phosphorylation levels in various cell types.The Phospho-p90RSK (T359/S363) Polyclonal Antibody is an essential tool for researchers studying cell signaling pathways, cancer biology, and drug development.
By targeting the phosphorylation sites of p90RSK, this antibody enables the precise analysis of p90RSK activity, offering valuable insights into its role in various cellular processes.Understanding the phosphorylation of p90RSK at threonine 359 and serine 363 is crucial for unraveling the complex signaling networks that govern cell growth and survival. By studying the regulation of p90RSK phosphorylation, researchers can identify new therapeutic targets for diseases such as cancer, where dysregulated p90RSK activity plays a critical role in tumor progression and metastasis.
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method:
Affinity purification
Gene ID:
6195
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of A431 cells, using Phospho-p90Rsk/RSK1/RPS6KA1-T359/S363 antibody (CABP0539).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
