The Phospho-p70 S6 Kinase (S371) Polyclonal Antibody (CABP1123) is specifically designed for researchers studying the phosphorylation of the p70 S6 kinase at serine 371. This rabbit polyclonal antibody is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the phosphorylated form of p70 S6 kinase at serine 371, this antibody enables the detection and analysis of this important signaling protein in various cell types.The phosphorylation of p70 S6 kinase at serine 371 is known to play a crucial role in the regulation of protein synthesis, cell growth, and proliferation. Dysregulation of this signaling pathway has been associated with various diseases, including cancer, making it a prime target for research in the field of oncology.
By studying the phosphorylation of p70 S6 kinase at serine 371, researchers can gain valuable insights into the mechanisms underlying cancer development and potentially identify new targets for therapeutic intervention.Overall, the Phospho-p70 S6 Kinase (S371) Polyclonal Antibody (CABP1123) is a valuable tool for researchers interested in elucidating the role of p70 S6 kinase phosphorylation in cellular signaling pathways, with potential implications for cancer research and drug development.
Antibody Name:
Anti-Phospho-p70 S6 kinase-S371 Antibody
Antibody SKU:
CABP1123
Antibody Size:
20uL, 50uL, 100uL
Application:
WB
Reactivity:
Mouse
Host Species:
Rabbit
Immunogen:
A phospho specific peptide corresponding to residues surrounding S371 of human RPS6KB1.
Application:
WB
Recommended Dilution:
WB 1:500 - 1:2000
Reactivity:
Mouse
Positive Samples:
NIH/3T3
Immunogen:
A phospho specific peptide corresponding to residues surrounding S371 of human RPS6KB1.
Purification Method:
Affinity purification
Storage Buffer:
Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]
UniProt Protein Function:
p70S6K: an AGC kinase of the RSK family that is required for cell growth and G1 cell cycle progression. Is phosphorylated and activated by mTOR in mitogenic pathways downstream of phosphoinositide 3 kinase (PI3K). Phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. Activity is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains. Mouse knockout shows symptoms of insulin resistance, and increased insulin senstivity, resulting in protection against diet-induced obesity. Protein expression and activation upregulated in colon adenocarcinoma cell lines. Increased expression in breast cancer correlated with poor survival. Selectively amplified and overexpressed within the 17q23 breast cancer amplicon. Two isoforms produced by alternative initiation have been reported.
UniProt Protein Details:
Protein type:EC 2.7.11.1; Translation; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Kinase, protein; AGC group; RSK family; p70 subfamily
Chromosomal Location of Human Ortholog: 17q23.1
NCBI Summary:
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]
