The Phospho-p38 MAPK (T180/Y182) Monoclonal Antibody (CABP1311) is a crucial tool for researchers studying the p38 MAPK signaling pathway, a key intracellular pathway involved in regulating cell responses to stress and inflammation. This antibody, developed for use in Western blot and immunohistochemistry applications, specifically targets the phosphorylated form of p38 MAPK at threonine 180 and tyrosine 182 residues. The activation of p38 MAPK plays a vital role in various cellular processes, including cell proliferation, differentiation, and apoptosis. Dysregulation of this pathway has been implicated in a wide range of diseases, including cancer, inflammatory conditions, and neurodegenerative disorders.
By targeting the phosphorylated form of p38 MAPK, researchers can gain valuable insights into the activation status of this pathway in different cell types and disease states.With its high reactivity in human samples and validated performance in various experimental techniques, the Phospho-p38 MAPK (T180/Y182) Monoclonal Antibody is a valuable tool for studies in immunology, cancer biology, and drug development. By elucidating the role of p38 MAPK phosphorylation in disease processes, researchers can potentially uncover new therapeutic targets and strategies for treating a variety of human health conditions.
Product Name:
Phospho-p38 MAPK-T180/Y182 Monoclonal Antibody
SKU:
CABP1311
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around T180 & Y182 of human MAPK(NP_002742.3).
This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Purification Method:
Affinity purification
Gene ID:
5600/6300/5603/1432
Clone Number:
ARC51018
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Phospho-p38MAPK-T180/Y182 antibody (CABP1311) at 1:20000 dilution.293T cells were treated by UV at room temperature for 15-30 minutes.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
