The Phospho-NDRG1 (T346) Polyclonal Antibody (CABP0792) is a cutting-edge tool for researchers studying NDRG1, a protein involved in various cellular processes including cell growth, apoptosis, and metastasis. This antibody, produced in rabbits, is highly specific to the phosphorylated form of NDRG1 at threonine 346 and is validated for use in Western blot applications. By targeting this phosphorylation site, researchers can gain insights into the signaling pathways and functions regulated by NDRG1 in different cell types.NDRG1, also known as N-Myc downstream-regulated gene 1, is a key player in tumor suppression and has been implicated in the progression of various cancer types.
The phosphorylation of NDRG1 at threonine 346 is particularly relevant in cancer research, as it has been linked to cell proliferation, invasion, and metastasis. By using this antibody, researchers can investigate the role of phospho-NDRG1 (T346) in cancer development and potentially identify new therapeutic targets for treating cancer.Overall, the Phospho-NDRG1 (T346) Polyclonal Antibody (CABP0792) is a valuable tool for researchers interested in understanding the molecular mechanisms governed by NDRG1 phosphorylation, with potential applications in cancer biology, cell signaling, and drug discovery.
Product Name:
Phospho-NDRG1-T346 Rabbit Polyclonal Antibody
SKU:
CABP0792
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around T346 of human NDRG1 (NP_001128714.1).
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
10397
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from C6 cells, using Phospho-NDRG1-T346 Rabbit pAb (CABP0792) at 1:1000 dilution.C6 cells were treated by IGF-1 (50 ng/ml) at 37℃ for 30 minutes after serum-starvation overnight.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
