Phospho-MYL12A/MYL12B/MYL9 (T17/S18) Antibody (PACO03360)
- SKU:
- PACO03360
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Phospho-MYL12A/MYL12B/MYL9 (T17/S18) Antibody (PACO03360)
The Phospho-MYL12A/MYL12B/MYL9 (T17/S18) Antibody (PACO03360) is a valuable tool for researchers studying cell signaling pathways involved in cellular functions such as cell motility, contraction, and cytoskeleton organization. This antibody, raised in rabbits, specifically targets phosphorylated forms of MYL12A, MYL12B, and MYL9 at threonine 17 and serine 18 residues.Phosphorylation of these myosin light chain proteins plays a crucial role in regulating actin-myosin interactions and controlling various cellular processes, including cell migration, adhesion, and division. The antibody is validated for use in applications such as Western blotting, immunofluorescence, and immunoprecipitation, allowing for the detection and analysis of phosphorylated MYL12A, MYL12B, and MYL9 in a variety of cell types.
Understanding the function and regulation of MYL12A, MYL12B, and MYL9 phosphorylation is essential for unraveling the complexities of cell signaling cascades and could provide valuable insights into diseases such as cancer, cardiovascular disorders, and smooth muscle-related pathologies. Researchers interested in studying the role of these proteins in cellular processes and disease pathogenesis will find the Phospho-MYL12A/MYL12B/MYL9 (T17/S18) Antibody (PACO03360) to be
| Antibody Name: | Phospho-MYL12A/MYL12B/MYL9 (T17/S18) Antibody |
| Antibody SKU: | PACO03360 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from human MLC-2 around the phosphorylation site of T17/S18. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | MYL12A; MLCB; MRLC3; RLC; Myosin regulatory light chain 12A; MLC-2B; Myosin RLC; Myosin regulatory light chain 2; nonsarcomeric; Myosin regulatory light chain MRLC3; MYL12B; MRLC2; MYLC2B; Myosin regulatory light chain 12B; MLC-2A; MLC-2; M |
| UniProt Protein Function: | MRLC3: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. Myosin is an hexamer of 2 heavy chains and 4 light chains. |
| UniProt Protein Details: | Protein type:Contractile Chromosomal Location of Human Ortholog: 18p11.31 Cellular Component: myosin II complex; stress fiber; cytosol; Z disc Molecular Function:protein binding; glutamate receptor binding; calcium ion binding Biological Process: axon guidance; regulation of cell shape; ephrin receptor signaling pathway |
| NCBI Summary: | This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014] |
| UniProt Code: | P19105 |
| NCBI GenInfo Identifier: | 127169 |
| NCBI Gene ID: | 10627 |
| NCBI Accession: | P19105.2 |
| UniProt Secondary Accession: | P19105,Q53X45, |
| UniProt Related Accession: | P19105 |
| Molecular Weight: | 171 |
| NCBI Full Name: | Myosin regulatory light chain 12A |
| NCBI Synonym Full Names: | myosin, light chain 12A, regulatory, non-sarcomeric |
| NCBI Official Symbol: | MYL12AÂ Â |
| NCBI Official Synonym Symbols: | MLCB; MRCL3; MRLC3; MYL2B; MLC-2B; HEL-S-24Â Â |
| NCBI Protein Information: | myosin regulatory light chain 12A; myosin RLC; myosin regulatory light chain 3; epididymis secretory protein Li 24; myosin regulatory light chain MRLC3; myosin regulatory light chain 2, nonsarcomeric; myosin, light polypeptide, regulatory, non-sarcomeric |
| UniProt Protein Name: | Myosin regulatory light chain 12A |
| UniProt Synonym Protein Names: | Epididymis secretory protein Li 24; HEL-S-24; MLC-2B; Myosin RLC; Myosin regulatory light chain 2, nonsarcomeric; Myosin regulatory light chain MRLC3 |
| Protein Family: | C-type mannose receptor |
| UniProt Gene Name: | MYL12AÂ Â |
| UniProt Entry Name: | ML12A_HUMAN |
Related Products
MYL12A/MYL12B/MYL9 Antibody (PACO03361)
MYL9/MYL12A Antibody (PACO01087)
Phospho-Histone H1 (T17) Antibody (PACO02807)
Phospho-PLN-T17 Rabbit Polyclonal Antibody (CABP0910)
Phospho-Histone H1.3-T17/Histone H1.4-T17 Rabbit Monoclonal Antibody (CABP1132)
Phospho-MYL9-T18/S19 Rabbit Polyclonal Antibody (CABP0955)
