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Phospho-c-Myc-S373 Rabbit Polyclonal Antibody (CABP0132)

SKU:
CABP0132
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
€419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Phospho-c-Myc-S373 Rabbit Polyclonal Antibody
SKU:CABP0132
Size:100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A phospho specific peptide corresponding to residues surrounding S373 of human c-Myc
Tested Applications:WB
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:MRTL; MYCC; c-Myc; bHLHe39; Phospho-c-Myc-S373
Positive Sample:A-431
Conjugate:Unconjugated
Cellular Localization:Nucleus, nucleolus, nucleoplasm.
Calculated MW:51kDa
Observed MW:60kDa

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.

Purification Method:Affinity purification
Gene ID:4609
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from A431 cells using Phospho-c-Myc-S373 Rabbit pAb (CABP0132).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.

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