Phospho-MYBL2 (S577) Antibody (PACO04374)
- SKU:
- PACO04374
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Phospho-MYBL2 (S577) Antibody (PACO04374)
The Phospho-MYBL2 (S577) Antibody (PACO04374) is a valuable tool for researchers studying MYBL2, a transcription factor involved in cell cycle regulation and cancer development. This antibody, raised in rabbits, specifically detects phosphorylation of MYBL2 at serine 577 in human samples, making it ideal for Western blot analyses.MYBL2 is a key regulator of cell division and has been implicated in various cancers, making it a potential target for cancer therapy. Phosphorylation of MYBL2 at serine 577 has been linked to its activity in controlling cell cycle progression, highlighting the importance of studying this modification in cancer research.
By using the Phospho-MYBL2 (S577) Antibody, researchers can gain insight into the role of MYBL2 phosphorylation in cancer development and progression. This antibody enables detection and analysis of phosphorylated MYBL2 in various cell types, providing valuable information for studies aimed at understanding the molecular mechanisms underlying cancer growth and metastasis.
| Antibody Name: | Phospho-MYBL2 (S577) Antibody |
| Antibody SKU: | PACO04374 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from human B-Myb around the phosphorylation site of S577. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | MYBL2; BMYB; Myb-related protein B; B-Myb; Myb-like protein 2 |
| UniProt Protein Function: | B-Myb: a transcription factor involved in cell cycle progression. Phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 20q13.1 Cellular Component: nucleoplasm Molecular Function:protein binding; chromatin binding; transcription factor activity Biological Process: transcription, DNA-dependent; regulation of cell cycle; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; G2/M transition of mitotic cell cycle |
| NCBI Summary: | The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013] |
| UniProt Code: | P10244 |
| NCBI GenInfo Identifier: | 127584 |
| NCBI Gene ID: | 4605 |
| NCBI Accession: | P10244.1 |
| UniProt Secondary Accession: | P10244,Q53F07, B2RBS5, B7Z8D9, F8W6N6, |
| UniProt Related Accession: | P10244 |
| Molecular Weight: | 75,865 Da |
| NCBI Full Name: | Myb-related protein B |
| NCBI Synonym Full Names: | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| NCBI Official Symbol: | MYBL2Â Â |
| NCBI Official Synonym Symbols: | BMYB; B-MYBÂ Â |
| NCBI Protein Information: | myb-related protein B; myb-like protein 2; v-myb myeloblastosis viral oncogene homolog-like 2 |
| UniProt Protein Name: | Myb-related protein B |
| UniProt Synonym Protein Names: | Myb-like protein 2 |
| Protein Family: | Myb-related protein |
| UniProt Gene Name: | MYBL2Â Â |
| UniProt Entry Name: | MYBB_HUMAN |
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