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Phospho-MERTK/TYRO3 (Y749/681) Antibody (PACO02319)

SKU:
PACO02319
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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Phospho-MERTK/TYRO3 (Y749/681) Antibody (PACO02319)

The Phospho-MERTK (Tyr749/681) Antibody (PACO02319) is a valuable tool for researchers studying the MERTK and Tyro3 receptors, both of which are involved in regulating immune responses and cell signaling pathways. This antibody, derived from rabbits, is highly specific to human samples and has been validated for use in Western blotting applications. By binding to the phosphorylated form of MERTK at Tyr749/681, this antibody enables the detection and analysis of MERTK activation in various cell types, making it ideal for studies in immunology, cancer research, and beyond.MERTK and Tyro3 are receptor tyrosine kinases that play important roles in regulating processes such as phagocytosis, cell survival, and inflammation.

The phosphorylation of MERTK at Tyr749/681 is a key event in the activation of downstream signaling pathways that promote cell growth and survival. Understanding the regulation of MERTK and Tyro3 signaling can provide valuable insights into immune function and the development of diseases such as cancer and autoimmune disorders.Overall, the Phospho-MERTK (Tyr749/681) Antibody (PACO02319) is a powerful tool for researchers interested in exploring the role of MERTK and Tyro3 receptors in immune regulation and cell signaling. Its high specificity and sensitivity make it a reliable option for studies aimed at uncovering the molecular mechanisms underlying immune responses and disease

Antibody Name:Phospho-MERTK/TYRO3 (Y749/681) Antibody
Antibody SKU:PACO02319
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from human MerTK/Tyro3 around the phosphorylation site of Y749/681.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:MERTK; MER; Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; TYRO3; BYK; DTK; RSE; SKY; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kin
UniProt Protein Function:Mer: a proto-oncogene receptor tyrosine-protein kinase of the Axl family. Binds several ligands including LGALS3, Tubby, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3
UniProt Protein Details:

Protein type:Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Oncoprotein; Kinase, protein; TK group; Axl family

Chromosomal Location of Human Ortholog: 2q14.1

Cellular Component: extracellular space; photoreceptor outer segment; integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function:protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: platelet activation; negative regulation of lymphocyte activation; peptidyl-tyrosine phosphorylation; vagina development; protein amino acid phosphorylation; phagocytosis; cell surface receptor linked signal transduction; cell-cell signaling; retina development in camera-type eye; natural killer cell differentiation; positive regulation of phagocytosis; protein kinase B signaling cascade; spermatogenesis; blood coagulation; leukocyte migration; apoptotic cell clearance; secretion by cell

Disease: Retinitis Pigmentosa 38

NCBI Summary:This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]
UniProt Code:Q12866
NCBI GenInfo Identifier:160332297
NCBI Gene ID:10461
NCBI Accession:Q12866.2
UniProt Secondary Accession:Q12866,Q9HBB4,
UniProt Related Accession:Q12866
Molecular Weight:999
NCBI Full Name:Tyrosine-protein kinase Mer
NCBI Synonym Full Names:MER proto-oncogene, tyrosine kinase
NCBI Official Symbol:MERTK  
NCBI Official Synonym Symbols:MER; RP38; c-Eyk; c-mer; Tyro12  
NCBI Protein Information:tyrosine-protein kinase Mer; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MerTK; c-mer proto-oncogene tyrosine kinase
UniProt Protein Name:Tyrosine-protein kinase Mer
UniProt Synonym Protein Names:Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK
Protein Family:Tyrosine-protein kinase
UniProt Gene Name:MERTK  
UniProt Entry Name:MERTK_HUMAN

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