Phospho-MERTK/TYRO3 (Tyr749/681) Antibody (PACO24391)
- SKU:
- PACO24391
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Phospho-MERTK/TYRO3 (Tyr749/681) Antibody (PACO24391)
The Phospho-MERTK (Tyr749/681) Antibody (PACO24391) is a high-quality research tool designed for studying the phosphorylation status of MERTK and its role in various cellular processes. This antibody, generated in rabbits, is specifically reactive with human samples and has been validated for use in Western blot applications. By binding to the phosphorylated forms of MERTK at tyrosine residues 749 and 681, this antibody allows for the detection and analysis of MERTK activation in different cell types.MERTK is a member of the TAM (Tyro3, Axl, Mer) family of receptor tyrosine kinases, known for their involvement in regulating cell survival, proliferation, and immune responses. Phosphorylation of MERTK at tyrosine residues 749 and 681 is a key event that modulates its kinase activity and downstream signaling pathways, making it a crucial target for studying the function of this receptor in various physiological and pathological contexts.
Research on MERTK and its phosphorylation status has implications in the fields of immunology, oncology, and inflammation, as dysregulation of MERTK signaling has been linked to diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. By using the Phospho-MERTK (Tyr749/681) Antibody, researchers can gain valuable insights into the role of MERTK phosphorylation in these disease settings and potentially identify novel therapeutic
| Antibody Name: | Phospho-MERTK/TYRO3 (Tyr749/681) Antibody (PACO24391) |
| Antibody SKU: | PACO24391 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000, IHC:1:50-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Peptide sequence around phosphorylation site of tyrosine 749/681(K-I-Y(p)-S-G) derived from Human MER/SKY . |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from 3T3 cells treated with EGF using MER/SKY (Phospho-Tyr749/681) Antibody.The lane on the right is treated with the antigen-specific peptide. |
 | Immunohistochemical analysis of paraffin-embedded human brain tissue using MER/SKY (Phospho-Tyr749/681) antibody (left)or the same antibody preincubated with blocking peptide (right). |
| Background: | This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). |
| Synonyms: | C-mer; MERK; MERTK; |
| UniProt Protein Function: | Mer: a proto-oncogene receptor tyrosine-protein kinase of the Axl family. Binds several ligands including LGALS3, Tubby, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Oncoprotein; Kinase, protein; TK group; Axl family Chromosomal Location of Human Ortholog: 2q14.1 Cellular Component: extracellular space; photoreceptor outer segment; integral to plasma membrane; cytoplasm; plasma membrane Molecular Function:protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: platelet activation; negative regulation of lymphocyte activation; peptidyl-tyrosine phosphorylation; vagina development; protein amino acid phosphorylation; phagocytosis; cell surface receptor linked signal transduction; cell-cell signaling; retina development in camera-type eye; natural killer cell differentiation; positive regulation of phagocytosis; protein kinase B signaling cascade; spermatogenesis; blood coagulation; leukocyte migration; apoptotic cell clearance; secretion by cell Disease: Retinitis Pigmentosa 38 |
| NCBI Summary: | This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q12866 |
| NCBI GenInfo Identifier: | 160332297 |
| NCBI Gene ID: | 10461 |
| NCBI Accession: | Q12866.2 |
| UniProt Secondary Accession: | Q12866,Q9HBB4, |
| UniProt Related Accession: | Q12866 |
| Molecular Weight: | 999 |
| NCBI Full Name: | Tyrosine-protein kinase Mer |
| NCBI Synonym Full Names: | MER proto-oncogene, tyrosine kinase |
| NCBI Official Symbol: | MERTKÂ Â |
| NCBI Official Synonym Symbols: | MER; RP38; c-Eyk; c-mer; Tyro12Â Â |
| NCBI Protein Information: | tyrosine-protein kinase Mer; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MerTK; c-mer proto-oncogene tyrosine kinase |
| UniProt Protein Name: | Tyrosine-protein kinase Mer |
| UniProt Synonym Protein Names: | Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK |
| Protein Family: | Tyrosine-protein kinase |
| UniProt Gene Name: | MERTKÂ Â |
| UniProt Entry Name: | MERTK_HUMAN |
| Antibodies |
| Phospho-MERTK/TYRO3 (Y749/681) Antibody (PACO02319) |
| MERTK/TYRO3 Antibody (PACO02320) |
| MERTK/TYRO3 Antibody (PACO06637) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Phospho-MERTK/TYRO3 (Y749/681) Antibody (PACO02319)
MERTK/TYRO3 Antibody (PACO06637)
MERTK/TYRO3 Antibody (PACO02320)
MERTK/TYRO3 (Ab-753) Antibody (PACO21647)
MERTK Antibody (CAB5443)
MERTK Monoclonal Antibody (CAB12294)
Human TYRO3 (Tyrosine-protein kinase receptor TYRO3) ELISA Kit (HUFI08058)
Phospho-ARHGAP31 (T789) Antibody (PACO04822)
