The Phospho-Merlin S518 Polyclonal Antibody (CABP0414) is a valuable tool for researchers studying the phosphorylation of the Merlin protein at serine 518. Merlin, also known as neurofibromin 2, is a tumor suppressor protein involved in cell growth regulation and cytoskeletal organization. Phosphorylation of Merlin at S518 has been linked to its function in cell proliferation and tumorigenesis.This antibody, raised in rabbits, has been validated for use in Western blotting applications and is highly reactive with human samples. By specifically binding to the phosphorylated form of Merlin at S518, this antibody allows for the detection and analysis of Merlin phosphorylation in various cell types.
This makes it an ideal tool for researchers studying signaling pathways, cell proliferation, and tumorigenesis in the context of cancer research.Understanding the regulation of Merlin phosphorylation at S518 is crucial for unraveling its role in cancer development and progression. By investigating the impact of this post-translational modification on Merlin function, researchers can gain insights into potential therapeutic targets for cancer treatment. The Phospho-Merlin S518 Polyclonal Antibody offers a reliable and specific tool for studying the phosphorylation status of Merlin in cancer biology and beyond.
Product Name:
Phospho-NF2-S518 Rabbit Polyclonal Antibody
SKU:
CABP0414
Size:
100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A phospho specific peptide corresponding to residues surrounding S518 of human NF2
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein's function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities.
Purification Method:
Affinity purification
Gene ID:
4771
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from HUVEC cells, using Phospho-NF2-S518 Rabbit pAb (CABP0414).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
