Phospho-MDM2-S166 Monoclonal Antibody (CABP1308)
- SKU:
- CABP1308
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Frequently bought together:
Description
Product Name: | Phospho-MDM2-S166 Monoclonal Antibody |
SKU: | CABP1308 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A phospho synthetic peptide corresponding to residues surrounding S166 of Human MDM2. |
Tested Applications: | IHC-P ELISA |
Recommended Dilution: | IHC-P,1:50 - 1:200 |
Synonyms: | HDMX; LSKB; hdm2; ACTFS; Phospho-MDM2-S166 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, Nucleolus, Nucleoplasm. |
Calculated MW: | 55kDa |
Observed MW: | Refer to figures |
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Purification Method: | Affinity purification |
Gene ID: | 4193 |
Clone Number: | ARC2909 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |