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Phospho-MARK1/MARK2/MARK3/MARK4 (T215) Antibody (PACO04294)

SKU:
PACO04294
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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Phospho-MARK1/MARK2/MARK3/MARK4 (T215) Antibody (PACO04294)

The Phospho-MARK1/MARK2/MARK3/MARK4 (T215) Antibody (PAC004294) is a valuable tool for researchers studying the MARK family of proteins involved in various cellular processes, including cell cycle regulation, cell polarity, and cell migration. This antibody, developed and validated by Assaygenie, specifically targets the phosphorylated form of MARK1, MARK2, MARK3, and MARK4 at threonine 215, allowing for precise detection and analysis in Western blot applications.Phosphorylation at threonine 215 is known to regulate the activity of MARK family members, influencing their downstream signaling pathways and cellular functions.

By utilizing the PAC004294 Antibody, researchers can investigate the role of these phosphorylated MARK proteins in different cellular contexts and diseases, such as neurodegenerative disorders, cancer, and neurodevelopmental abnormalities.With its high reactivity towards human samples and robust validation for Western blotting, the Phospho-MARK1/MARK2/MARK3/MARK4 (T215) Antibody is an essential tool for advancing our understanding of the MARK family and its implications in various pathological conditions.

Antibody Name:Phospho-MARK1/MARK2/MARK3/MARK4 (T215) Antibody
Antibody SKU:PACO04294
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:IHC:1:100-1:300
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from human MARK1/2/3/4 around the phosphorylation site of T215.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:MARK1; KIAA1477; MARK; Serine/threonine-protein kinase MARK1; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c; MARK2; EMK1; Serine/threonine-protein kinase MARK2; ELKL motif kinase 1; EMK-1; MAP/microtubule affin
UniProt Protein Function:MARK1: a member of the CAMKL family of protein kinases. The MARK group of kinases is apparently involved in the control of cell polarity, microtubule stability and cancer. MARK1 forms a tight association with Tau in neurofibrillary tangles in Alzheimer disease tissue.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; EC 2.7.11.1; EC 2.7.11.26; CAMK group; CAMKL family; MARK subfamily

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: cytoplasm; cytoskeleton; microtubule cytoskeleton; plasma membrane

Molecular Function:ATP binding; magnesium ion binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; protein serine/threonine kinase activity; tau-protein kinase activity

Biological Process: cytoskeleton organization and biogenesis; neuron migration; protein amino acid phosphorylation; Wnt receptor signaling pathway

UniProt Code:Q9P0L2
NCBI GenInfo Identifier:124056494
NCBI Gene ID:4139
NCBI Accession:Q9P0L2.2
UniProt Secondary Accession:Q9P0L2,Q2HIY1, Q5VTF9, Q5VTG0, Q96SW9, Q9P251, D3DTB0 D3DTB1,
UniProt Related Accession:Q9P0L2
Molecular Weight:84,911 Da
NCBI Full Name:Serine/threonine-protein kinase MARK1
NCBI Synonym Full Names:microtubule affinity regulating kinase 1
NCBI Official Symbol:MARK1  
NCBI Official Synonym Symbols:MARK; Par1c; Par-1c  
NCBI Protein Information:serine/threonine-protein kinase MARK1
UniProt Protein Name:Serine/threonine-protein kinase MARK1
UniProt Synonym Protein Names:MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:MARK1  
UniProt Entry Name:MARK1_HUMAN

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