The Phospho-MAPT (S396) polyclonal antibody (CABP0163) is a valuable tool for researchers studying the MAPT protein, also known as tau protein, which plays a crucial role in Alzheimer's disease and other neurodegenerative disorders. This antibody, raised in rabbits, is highly specific to the phosphorylated form of MAPT at serine 396 and is validated for use in various research applications, including immunohistochemistry and immunofluorescence.The phosphorylation of MAPT at serine 396 is known to affect its function in microtubule stabilization and neuronal cell morphology. Dysregulation of this phosphorylation event has been implicated in the pathogenesis of Alzheimer's disease and other tauopathies.
Therefore, studying the phosphorylation status of MAPT at serine 396 can provide valuable insights into the molecular mechanisms underlying these devastating neurological conditions.With its high specificity and sensitivity, the Phospho-MAPT (S396) polyclonal antibody (CABP0163) is an essential tool for researchers investigating the role of MAPT phosphorylation in neurodegenerative diseases. Its ability to selectively bind to the phosphorylated form of MAPT at serine 396 makes it an ideal reagent for studies aimed at understanding the pathophysiological mechanisms associated with tau protein dysfunction.
Product Name:
Phospho-Tau-S396 Rabbit Polyclonal Antibody
SKU:
CABP0163
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around S396 of human Tau (NP_058519.3).
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Purification Method:
Affinity purification
Gene ID:
4137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from SH-SY5Y cells, using Phospho-Tau-S396 Rabbit pAb (CABP0163) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
