The Phospho-MAPT (S262) Polyclonal Antibody (CABP0397) is a valuable tool for researchers studying MAPT, a protein involved in regulating microtubule dynamics and neuronal function. This antibody, produced in rabbits, demonstrates high specificity for human samples and is suitable for use in Western blot applications. By targeting the phosphorylated form of MAPT at S262, this antibody allows for the detection and analysis of MAPT in different cell types, making it ideal for investigations in neuroscience and neurodegenerative diseases.MAPT, also known as tau protein, plays a crucial role in maintaining the structural integrity of neurons and supporting axonal transport. Dysregulation of MAPT phosphorylation, such as phosphorylation at S262, has been linked to various neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease.
By studying the phosphorylation status of MAPT, researchers can gain insights into the pathogenesis of these diseases and potentially develop targeted interventions that modulate MAPT function.Overall, the Phospho-MAPT (S262) Polyclonal Antibody (CABP0397) is a valuable tool for investigating the role of MAPT in neurobiology and neurodegenerative diseases, providing researchers with a means to further understand the mechanisms underlying these conditions and potentially identify new therapeutic targets.
Product Name:
Phospho-Tau-S262 Rabbit Polyclonal Antibody
SKU:
CABP0397
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around S262 of Tau (NP_058518.1).
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Purification Method:
Affinity purification
Gene ID:
4137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain, using Phospho-Tau-S262 Rabbit pAb (CABP0397) at 1:500 dilution.Mouse brain were treated by CIP(20uL/400ul) at 37℃ for 1 hour.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 120s.
