The Phospho-MAPKAPK2 (T334) Polyclonal Antibody (CABP0396) is a valuable tool for researchers studying MAPKAPK2, a protein kinase involved in cellular stress response pathways. This antibody, generated in rabbits, exhibits high specificity for detecting phosphorylation of MAPKAPK2 at threonine 334 in human samples and is suitable for Western blot applications. By targeting the phosphorylated form of MAPKAPK2, researchers can gain insight into the activation and regulation of this important signaling molecule in various cellular processes.MAPKAPK2 is a key regulator of cell growth, differentiation, and apoptosis in response to extracellular stimuli. Phosphorylation at threonine 334 is known to enhance the kinase activity of MAPKAPK2, influencing downstream signaling cascades that impact cell survival and proliferation.
Investigating the phosphorylation status of MAPKAPK2 provides valuable information on its role in stress responses and its potential as a therapeutic target for diseases associated with dysregulated cell signaling.Overall, the Phospho-MAPKAPK2 (T334) Polyclonal Antibody (CABP0396) offers researchers a reliable and specific tool for studying the phosphorylation status of MAPKAPK2 in various experimental settings, including cancer research, inflammation, and cellular stress response pathways. Its ability to detect phosphorylated MAPKAPK2 at threonine 334 provides a deeper understanding
Product Name:
Phospho-MAPKAPK2-T334 Rabbit Polyclonal Antibody
SKU:
CABP0396
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around T334 of human MAPKAPK2 (NP_116584.2?).
Sequence:
PQTP L
Tested Applications:
IHC-PELISA
Recommended Dilution:
IHC-P,1:50 - 1:100
Synonyms:
MK2; MK-2; MAPKAP-K2; Phospho-MAPKAPK-2/MK2-T334
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
46kDa
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9261
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Mouse kidney using Phospho-MAPKAPK-2/MK2-T334 Rabbit pAb (CABP0396) at dilution of 1:200 (40x lens).Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
