The p38 MAPK Polyclonal Antibody is a valuable tool for researchers studying the p38 Mitogen-Activated Protein Kinase (MAPK) pathway, a key signaling pathway involved in cellular responses to stress and inflammation. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot and immunohistochemistry applications.The p38 MAPK pathway is known to play a critical role in a variety of cellular processes such as cell proliferation, differentiation, and apoptosis. Dysregulation of this pathway has been implicated in various diseases including cancer, inflammatory conditions, and neurodegenerative disorders.
By targeting and detecting the p38 MAPK protein, researchers can gain insights into the molecular mechanisms underlying these diseases and potentially identify novel therapeutic targets.Overall, the p38 MAPK Polyclonal Antibody is a reliable tool for investigating the role of the p38 MAPK pathway in both normal physiological processes and disease states. Its high specificity and validation for various experimental techniques make it an essential component for studies in cell signaling, drug discovery, and biomarker identification.
Product Name:
p38 MAPK Rabbit Polyclonal Antibody
SKU:
CAB0227
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 261-360 of human p38 MAPK (NP_620581.1).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Purification Method:
Affinity purification
Gene ID:
1432
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using p38 MAPK Rabbit pAb (CAB0227) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
