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Phospho-MEK2-T394 Rabbit Polyclonal Antibody (CABP0121)

SKU:
CABP0121
Product Type:
Antibody
Applications:
WB
IHC
IF
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 16 Anti-Phospho-MAP2K2-T394 Antibody CABP0121
  • Cell Biology Antibodies 16 Anti-Phospho-MAP2K2-T394 Antibody CABP0121
  • Cell Biology Antibodies 16 Anti-Phospho-MAP2K2-T394 Antibody CABP0121
€419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Phospho-MEK2-T394 Rabbit Polyclonal Antibody
SKU:CABP0121
Size:100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A phospho specific peptide corresponding to residues surrounding T394 of human MEK2
Tested Applications:WB IF/ICC
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:100 - 1:200
Synonyms:CFC4; MEK2; MKK2; MAPKK2; PRKMK2; Phospho-MEK2-T394
Positive Sample:HepG2
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Membrane, Peripheral membrane protein.
Calculated MW:44kDa
Observed MW:44kDa

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Purification Method:Affinity purification
Gene ID:5605
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from HepG2 cells using Phospho-MEK2-T394 Rabbit pAb (CABP0121).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.

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