Phospho-Lamin A/C-S22 Rabbit Polyclonal Antibody (CABP0777)
- SKU:
- CABP0777
- Product Type:
- Antibody
- Applications:
- WB
- IP
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | Phospho-Lamin A/C-S22 Rabbit Polyclonal Antibody |
SKU: | CABP0777 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | A synthetic phosphorylated peptide around S22 of human Lamin A (NP_005563.1). |
Sequence: | PLSP T |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; MADA; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B; Phospho-Lamin A/C-S22 |
Positive Sample: | HeLa,C6 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus, Nucleus envelope, Nucleus lamina, Nucleus speckle, nucleoplasm. |
Calculated MW: | 74kDa |
Observed MW: | 69kDa, 78kDa |
The protein encoded by this gene is part of the nuclear lamina, a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Purification Method: | Affinity purification |
Gene ID: | 4000 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |