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Phospho-KDR/FLT4 (Y1054/Y1063) Antibody (PACO04171)

SKU:
PACO04171
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
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Description

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Phospho-KDR/FLT4 (Y1054/Y1063) Antibody (PACO04171)

The Phospho-KDR/FLT4 (Y1054/Y1063) Antibody (PAC004171) is a highly specific antibody designed for research involving the phosphorylation of the KDR and FLT4 proteins at tyrosine residues 1054 and 1063. This antibody, raised in rabbits, is validated for use in Western blot applications and is highly reactive with human samples.KDR (also known as VEGFR2) and FLT4 (also known as VEGFR3) are receptor tyrosine kinases that play key roles in regulating angiogenesis and lymphangiogenesis, respectively. Phosphorylation at specific tyrosine residues is crucial for activating signaling pathways that promote blood vessel and lymph vessel formation.

Understanding the phosphorylation status of KDR and FLT4 in various cell types is essential for studying their functions in angiogenesis and lymphangiogenesis, making this antibody an invaluable tool for researchers in the fields of vascular biology, cancer research, and developmental biology. Its high specificity and reactivity with human samples make it ideal for investigating the roles of KDR and FLT4 in various physiological and pathological processes.

Antibody Name:Phospho-KDR/FLT4 (Y1054/Y1063) Antibody
Antibody SKU:PACO04171
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:IHC:1:100-1:300
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from human Flk-1/Flt-4 around the phosphorylation site of Y1054/Y1063.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:KDR; FLK1; VEGFR2; Vascular endothelial growth factor receptor 2; VEGFR-2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; KDR; Protein-tyrosine kinase receptor flk-1; CD antigen CD309; FLT4; VEGFR3; Vascular endothelial growth
UniProt Protein Function:VEGFR2: a receptor tyrosine kinase of the VEGFR family. High affinity receptor for VEGF and VEGF-C. Ligand binding induces autophosphorylation and activation. Activated receptor recruits proteins including Shc, GRB2, PI3K, Nck, SHP-1 and SHP-2. Plays a key role in vascular development and regulation of vascular permeability.
UniProt Protein Details:

Protein type:Protein kinase, TK; Kinase, protein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; VEGFR family

Chromosomal Location of Human Ortholog: 4q11-q12

Cellular Component: Golgi apparatus; endoplasmic reticulum; integral to plasma membrane; early endosome; cytoplasmic membrane-bound vesicle; extracellular region; plasma membrane; cell junction; nucleus; endosome; lipid raft; external side of plasma membrane

Molecular Function:integrin binding; vascular endothelial growth factor receptor activity; protein binding; growth factor binding; protein-tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; Hsp90 protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: extracellular matrix organization and biogenesis; positive regulation of positive chemotaxis; peptidyl-tyrosine phosphorylation; viral reproduction; protein amino acid autophosphorylation; cell maturation; calcium ion homeostasis; regulation of cell shape; positive regulation of MAPKKK cascade; positive regulation of focal adhesion formation; ovarian follicle development; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; angiogenesis; vasculogenesis; endothelial cell differentiation; cell fate commitment; embryonic hemopoiesis; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of angiogenesis; cell migration during sprouting angiogenesis; branching morphogenesis of a tube; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; lymph vessel development; vascular endothelial growth factor receptor signaling pathway; alveolus development; surfactant homeostasis; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis; positive regulation of cell migration; positive regulation of nitric-oxide synthase biosynthetic process

Disease: Hemangioma, Capillary Infantile

NCBI Summary:Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
UniProt Code:P35968
NCBI GenInfo Identifier:9087218
NCBI Gene ID:3791
NCBI Accession:P35968.2
UniProt Secondary Accession:P35968,O60723, Q14178, A2RRS0, B5A925, C5IFA0,
UniProt Related Accession:P35968
Molecular Weight:79,634 Da
NCBI Full Name:Vascular endothelial growth factor receptor 2
NCBI Synonym Full Names:kinase insert domain receptor (a type III receptor tyrosine kinase)
NCBI Official Symbol:KDR  
NCBI Official Synonym Symbols:FLK1; CD309; VEGFR; VEGFR2  
NCBI Protein Information:vascular endothelial growth factor receptor 2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor
UniProt Protein Name:Vascular endothelial growth factor receptor 2
UniProt Synonym Protein Names:Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; KDR; Protein-tyrosine kinase receptor flk-1; CD_antigen: CD309
Protein Family:Vascular endothelial growth factor receptor
UniProt Gene Name:KDR  
UniProt Entry Name:VGFR2_HUMAN

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