The Phospho-KCNJ16 (S416) Antibody (PAC003309) is a valuable tool for studying the phosphorylation of KCNJ16 at serine 416, a key regulatory event in ion channel function. This antibody, produced in rabbits, exhibits high specificity for human samples and has been rigorously validated for use in Western blotting applications. By targeting the phosphorylated form of KCNJ16, this antibody enables precise detection and analysis of this protein variant in various cell types, making it an essential tool for researchers in the fields of neuroscience and cardiovascular biology.KCNJ16, also known as Kir5.1, is a potassium channel subunit that plays a crucial role in maintaining potassium homeostasis and regulating membrane potential in excitable cells.
The phosphorylation of KCNJ16 at serine 416 has been implicated in modulating channel activity and has therefore garnered significant interest in the study of neurological disorders, cardiac arrhythmias, and other conditions related to ion channel dysfunction. By using the Phospho-KCNJ16 (S416) Antibody, researchers can gain valuable insights into the regulatory mechanisms governing KCNJ16 function and explore potential therapeutic targets for related diseases.
Antibody Name:
Phospho-KCNJ16 (S416) Antibody
Antibody SKU:
PACO03309
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC, IF
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from human KIR5.1 around the phosphorylation site of S416.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K+ recycling in distal tubules; this process is critical for Na+ reabsorption at the tubules.
