KCNJ11 Rabbit Polyclonal Antibody (CAB5765)
- SKU:
- CAB5765
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
Product Name: | KCNJ11 Rabbit Polyclonal Antibody |
SKU: | CAB5765 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 171-390 of human KCNJ11 (NP_000516.3). |
Sequence: | TAQA HRRA ETLI FSKH AVIA LRHG RLCF MLRV GDLR KSMI ISAT IHMQ VVRK TTSP EGEV VPLH QVDI PMEN GVGG NSIF LVAP LIIY HVID ANSP LYDL APSD LHHH QDLE IIVI LEGV VETT GITT QART SYLA DEIL WGQR FVPI VAEE DGRY SVDY SKFG NTVK VPTP LCTA RQLD EDHS LLEA LTLA SARG PLRK RSVP MAKA KPKF SISP DSLS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | BIR; HHF2; PHHI; IKATP; PNDM2; TNDM3; KIR6.2; MODY13; KCNJ11 |
Positive Sample: | SKOV3,HepG2,SW620,Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Multi-pass membrane protein. |
Calculated MW: | 44kDa |
Observed MW: | 31-43kDa |
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Purification Method: | Affinity purification |
Gene ID: | 3767 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |