The KCNIP3 Polyclonal Antibody (CAB13711) is a valuable tool for researchers studying KCNIP3, a key protein involved in ion channel regulation and neuronal function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically targeting the KCNIP3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it well-suited for research in neurobiology and neuroscience.KCNIP3, also known as potassium channel-interacting protein 3, is essential for the proper functioning of potassium channels in the brain, which play a crucial role in neuronal excitability and synaptic transmission.
Dysregulation of KCNIP3 has been linked to neurological disorders such as epilepsy and Alzheimer's disease, making it a promising target for therapeutic intervention. Understanding the role of KCNIP3 in ion channel function is key to advancing research and treatment options in the field of neuroscience.
Product Name:
KCNIP3 Rabbit Polyclonal Antibody
SKU:
CAB13711
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KCNIP3 (NP_038462.1).
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
30818
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from rat heart, using KCNIP3 Rabbit pAb (CAB13711) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
