The Phospho-KCNB1 S805 Antibody (PAC0059) is a valuable tool for studying the phosphorylation of KCNB1 at serine 805, a crucial event in the regulation of potassium ion channels and neuronal excitability. This antibody, raised against the phospho-KCNB1 S805 peptide, specifically recognizes the phosphorylated form of KCNB1 in samples from various species, making it a versatile reagent for research in neuroscience and cell signaling.KCNB1, a voltage-gated potassium channel subunit, plays a critical role in controlling the membrane potential and excitability of neurons. Phosphorylation of KCNB1 at serine 805 has been shown to modulate channel activity and impact neuronal function. By targeting this specific phosphorylation site, the PAC0059 antibody allows for the detection and quantification of phospho-KCNB1 S805 levels in cell lysates and tissue samples, providing valuable insights into the regulatory mechanisms of potassium channels in the nervous system.
Researchers interested in investigating the role of potassium channels in neural signaling, synaptic transmission, and neuronal diseases will find the Phospho-KCNB1 S805 Antibody (PAC0059) to be an essential tool for their studies. Its high specificity and sensitivity make it a reliable reagent for Western blotting and immunohistochemistry applications, paving the way for deeper insights into the molecular mechanisms governing neuronal excitability and synaptic plasticity.
Antibody Name:
Phospho-KCNB1 (S805) Antibody (PACO05959)
Antibody SKU:
PACO05959
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:40000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from human KV2.1 around the phosphorylation site of S805.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
KCNB1; Potassium voltage-gated channel subfamily B member 1; Delayed rectifier potassium channel 1; DRK1; h-DRK1; Voltage-gated potassium channel subunit Kv2.1
UniProt Protein Function:
Kv2.1: a potassium voltage-gated channel protein of subfamily B. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting K ions pass in accordance with their electrochemical gradient.Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Channel, cation; Channel, ligand-gatedChromosomal Location of Human Ortholog: 20q13.2Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; dendrite; plasma membrane; integral to membraneMolecular Function: protein binding; outward rectifier potassium channel activity; delayed rectifier potassium channel activity; protein N-terminus bindingBiological Process: synaptic transmission; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerizationDisease: Epileptic Encephalopathy, Early Infantile, 26
UniProt Protein Details:
NCBI Summary:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]
