The Phospho-KCNB1 (S567) Antibody (PAC005960) is a valuable tool for researchers studying potassium channels in cellular signaling processes. This antibody, generated in mice, specifically targets the phosphorylated form of KCNB1 at serine 567, enabling precise detection and analysis in Western blot applications. It is compatible with human samples and suitable for use in various cell types, making it an essential component for studies in neuroscience, cardiovascular research, and drug development.KCNB1, also known as the voltage-gated potassium channel subunit Kv2.1, plays a crucial role in regulating membrane potential and action potential in excitable cells. Phosphorylation at serine 567 is known to modulate channel activity, influencing neuronal excitability and cardiac function.
Research into the phosphorylation status of KCNB1 can provide insights into the mechanisms underlying neurological disorders, arrhythmias, and other conditions related to potassium channel dysfunction.By targeting the phosphorylated form of KCNB1, the Phospho-KCNB1 (S567) Antibody offers researchers a powerful tool to explore the role of potassium channels in cellular physiology and disease pathogenesis. Its high specificity and sensitivity make it an essential reagent for advancing our understanding of potassium channel regulation and developing targeted therapies for related disorders.
Antibody Name:
Phospho-KCNB1 (S567) Antibody (PACO05960)
Antibody SKU:
PACO05960
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC, IF
Recommended Dilutions:
ELISA:1:10000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from human Kv2.1 around the phosphorylation site of S567.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
KCNB1; Potassium voltage-gated channel subfamily B member 1; Delayed rectifier potassium channel 1; DRK1; h-DRK1; Voltage-gated potassium channel subunit Kv2.1
UniProt Protein Function:
Kv2.1: a potassium voltage-gated channel protein of subfamily B. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting K ions pass in accordance with their electrochemical gradient.Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Channel, cation; Channel, ligand-gatedChromosomal Location of Human Ortholog: 20q13.2Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; dendrite; plasma membrane; integral to membraneMolecular Function: protein binding; outward rectifier potassium channel activity; delayed rectifier potassium channel activity; protein N-terminus bindingBiological Process: synaptic transmission; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerizationDisease: Epileptic Encephalopathy, Early Infantile, 26
UniProt Protein Details:
NCBI Summary:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]
