The Phospho-Jun (S243) Polyclonal Antibody (CABP0050) is a powerful tool for researchers studying the Jun protein, a key regulator of cell proliferation, differentiation, and apoptosis. This antibody, generated in rabbits, is highly specific for detecting phosphorylation of Jun at serine 243 in human samples, making it suitable for a variety of applications including Western blotting and immunohistochemistry.Jun is a transcription factor that forms the AP-1 complex with other proteins to regulate gene expression in response to various cellular stimuli. Phosphorylation at serine 243 is known to modulate Jun's activity, leading to changes in gene transcription that can impact cell growth and survival.
By using this antibody, researchers can gain insights into the signaling pathways that control Jun phosphorylation and its downstream effects on cellular processes.Studying the phosphorylation of Jun at serine 243 is essential for understanding its role in diseases such as cancer, where dysregulation of Jun activity can promote tumor growth and metastasis. By utilizing the Phospho-Jun (S243) Polyclonal Antibody, researchers can uncover new therapeutic targets and develop strategies to manipulate Jun signaling for the treatment of cancer and other related disorders.
Product Name:
Phospho-c-Jun-S243 Rabbit Polyclonal Antibody
SKU:
CABP0050
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around S243 of human Jun (NP_002219.1).
Sequence:
PLSP I
Tested Applications:
WBIHC-PELISA
Recommended Dilution:
WB,1:500 - 1:2000 IHC-P,1:50 - 1:200
Synonyms:
AP1; p39; AP-1; cJUN; c-Jun; Phospho-c-Jun-S243
Positive Sample:
293,NIH/3T3
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
36kDa
Observed MW:
Refer to figures
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.
Purification Method:
Affinity purification
Gene ID:
3725
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Human colon carcinoma using Phospho-c-Jun-S243 Rabbit pAb (CABP0050) at dilution of 1:20 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
