Anti-Phospho-Jak3-Y980/981 Antibody (CABP0532)
- SKU:
- CABP0532
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
Anti-Phospho-Jak3-Y980/981 Antibody (CABP0532)
The Phospho-JAK3 (Y980/981) Polyclonal Antibody (CABP0532) is a valuable tool for researchers studying the phosphorylation of JAK3, a member of the Janus kinase family involved in cytokine receptor signaling and immune cell development. This antibody, produced in rabbits, is highly specific for detecting phosphorylation at tyrosine residues 980 and 981 of the JAK3 protein in human samples. Validated for use in Western blot applications, it allows for precise analysis of JAK3 phosphorylation levels in various cell types.JAK3 is a key player in cytokine signaling pathways that regulate immune responses, making it a critical target for understanding immune system function and dysfunction. Phosphorylation of JAK3 at Y980/981 has been implicated in the activation of downstream signaling events that control cell proliferation, differentiation, and survival.
Studying the phosphorylation status of JAK3 provides insights into the mechanisms underlying immune-related diseases such as cancer, autoimmune disorders, and inflammatory conditions.By utilizing the Phospho-JAK3 (Y980/981) Polyclonal Antibody, researchers can gain a deeper understanding of the role of JAK3 phosphorylation in immune signaling pathways and disease pathogenesis. This antibody is a valuable tool for advancing research in immunology, oncology, and therapeutic development aimed at targeting JAK3 for clinical interventions.
| Antibody Name: | Anti-Phospho-Jak3-Y980/981 Antibody |
| Antibody SKU: | CABP0532 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around Y980 of human Jak3 (NP_000206.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T |
| Immunogen: | A synthetic phosphorylated peptide around Y980 of human Jak3 (NP_000206.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KDYY V |
| Gene ID: | 3718 |
| Uniprot: | P52333 |
| Cellular Location: | Cytoplasm, Endomembrane system, Peripheral membrane protein |
| Calculated MW: | 68kDa/121kDa/125kDa |
| Observed MW: | 110kDa |
 | Western blot analysis of extracts of 293T cells, using Phospho-Jak3-Y980/981 antibody (CABP0532). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. |
| Synonyms: | JAK3, JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK |
| Background: | The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). |
| UniProt Protein Function: | JAK3: a non-receptor tyrosine-kinase of the Jak family expressed predominantly in immune cells. Mediates signal transduction via the common gamma-chain of cytokine receptors, including IL-2, -4, -7, -9, and -15. Interacts with members of the STAT (signal transduction and activators of transcription) family. Interacts with STAM2 and SHB. Contains two protein kinase domains. Mutations that abrogate JAK3 function cause an autosomal SCID (severe combined immunodeficiency disease). Inhibitor: R017s for organ transplants. Three differentially spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Kinase, protein; TK group; JakA family Chromosomal Location of Human Ortholog: 19p13.1 Cellular Component: cytoskeleton; cytosol; endomembrane system; extrinsic to internal side of plasma membrane Molecular Function:ATP binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein phosphatase binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor binding Biological Process: adaptive immune response; B cell differentiation; cell migration; elevation of cytosolic calcium ion concentration; enzyme linked receptor protein signaling pathway; innate immune response; MAPKKK cascade; negative regulation of dendritic cell cytokine production; negative regulation of FasL biosynthetic process; negative regulation of interleukin-10 production; negative regulation of interleukin-12 production; negative regulation of T cell activation; negative regulation of T-helper 1 cell differentiation; peptidyl-tyrosine phosphorylation; positive regulation of activated T cell proliferation; positive regulation of calcium ion transport; positive regulation of GTPase activity; positive regulation of immune response; positive regulation of T cell proliferation; protein amino acid phosphorylation; STAT protein nuclear translocation; T cell homeostasis; tyrosine phosphorylation of STAT protein; tyrosine phosphorylation of Stat5 protein Disease: Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-negative, B Cell-positive, Nk Cell-negative |
| NCBI Summary: | The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008] |
| UniProt Code: | P52333 |
| NCBI GenInfo Identifier: | 50403745 |
| NCBI Gene ID: | 3718 |
| NCBI Accession: | P52333.2 |
| UniProt Secondary Accession: | P52333,Q13259, Q13260, Q13611, Q8N1E8, Q99699, Q9Y6S2 |
| UniProt Related Accession: | P52333 |
| Molecular Weight: | |
| NCBI Full Name: | Tyrosine-protein kinase JAK3 |
| NCBI Synonym Full Names: | Janus kinase 3 |
| NCBI Official Symbol: | JAK3Â Â |
| NCBI Official Synonym Symbols: | JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMANÂ Â |
| NCBI Protein Information: | tyrosine-protein kinase JAK3 |
| UniProt Protein Name: | Tyrosine-protein kinase JAK3 |
| UniProt Synonym Protein Names: | Janus kinase 3; JAK-3; Leukocyte janus kinase; L-JAK |
| Protein Family: | Tyrosine-protein kinase |
| UniProt Gene Name: | JAK3Â Â |
| UniProt Entry Name: | JAK3_HUMAN |
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