The Phospho-IRS1 (S312) Polyclonal Antibody (CABP0181) is a valuable tool for researchers studying IRS1 phosphorylation at serine 312, a key post-translational modification that regulates insulin signaling pathways. This antibody, produced in rabbits, exhibits high specificity for human samples and is suitable for use in Western blotting experiments. By binding specifically to the phosphorylated form of IRS1 at serine 312, this antibody enables precise detection and quantification of this critical signaling event in various cell types.IRS1 is a key mediator of insulin signaling, playing a crucial role in the regulation of glucose and lipid metabolism. Phosphorylation of IRS1 at serine 312 has been implicated in the development of insulin resistance, a hallmark of metabolic disorders such as type 2 diabetes.
Understanding the mechanisms underlying IRS1 phosphorylation at this site is essential for unraveling the pathogenesis of insulin resistance and developing novel therapeutic strategies for metabolic diseases.Researchers studying signal transduction pathways related to insulin signaling, metabolism, and diabetes will find the Phospho-IRS1 (S312) Polyclonal Antibody (CABP0181) to be a valuable asset in their experiments. Its high specificity and sensitivity make it an ideal tool for investigating the role of IRS1 phosphorylation in health and disease.
Product Name:
Phospho-IRS1-S312 Rabbit Polyclonal Antibody
SKU:
CABP0181
Size:
100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A phospho specific peptide corresponding to residues surrounding S312 of human IRS1
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
Purification Method:
Affinity purification
Gene ID:
3667
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from 293 cells, using Phospho-IRS1-S312 Rabbit pAb (CABP0181).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
