Phospho-IRE1-S724 Rabbit Polyclonal Antibody (CABP0878)
- SKU:
- CABP0878
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | Phospho-IRE1-S724 Rabbit Polyclonal Antibody |
SKU: | CABP0878 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic phosphorylated peptide around S724 of human IRE1alpha (NP_001424.3). |
Sequence: | GRHS FS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | IRE1; IRE1P; IRE1a; hIRE1p; Phospho-IRE1-S724 |
Positive Sample: | NIH/3T3 |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Single-pass type I membrane protein. |
Calculated MW: | 110kDa |
Observed MW: | 126kDa |
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.
Purification Method: | Affinity purification |
Gene ID: | 2081 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |