The Phospho-IGF1R (Y1280) Polyclonal Antibody (CABP0368) is a valuable tool for researchers studying the insulin-like growth factor 1 receptor (IGF1R) and its phosphorylation at tyrosine 1280. This antibody, produced in rabbits, is highly specific to human samples and is optimized for use in Western blot applications.IGF1R is a transmembrane receptor tyrosine kinase that plays a crucial role in cell growth, proliferation, and survival. Phosphorylation at tyrosine 1280 is known to be important for the activation of downstream signaling pathways involved in cell growth and metabolism. By targeting this specific phosphorylation site, researchers can gain valuable insights into the mechanisms of IGF1R signaling in various cell types.
This antibody is a reliable tool for studying the role of Phospho-IGF1R (Y1280) in diseases such as cancer, where dysregulation of IGF1R signaling is commonly observed. By understanding the phosphorylation status of IGF1R at tyrosine 1280, researchers can potentially identify novel therapeutic targets for cancer treatment. Additionally, this antibody may also be useful for investigating the role of IGF1R in other physiological processes, such as insulin signaling and metabolic regulation.
Product Name:
Phospho-IGF1R-Y1280 Rabbit Polyclonal Antibody
SKU:
CABP0368
Size:
100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A phospho specific peptide corresponding to residues surrounding Y1280 of human IGF1R
Tested Applications:
WB
Recommended Dilution:
WB,1:500 - 1:2000
Synonyms:
IGFR; CD221; IGFIR; JTK13; Phospho-IGF1R-Y1280
Positive Sample:
293
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
155kDa
Observed MW:
95kDa
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3480
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from 293 cells, using Phospho-IGF1R-Y1280 Rabbit pAb (CABP0368).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
