The Phospho-IGF1R (Y1161) Polyclonal Antibody (CABP0367) is a valuable tool for researchers studying the Insulin-like Growth Factor 1 Receptor (IGF1R) signaling pathway. This antibody is raised in rabbits and is highly specific for detecting phosphorylation at tyrosine 1161 of the IGF1R protein. Validated for use in Western blot applications, this antibody allows for the detection and analysis of phosphorylated IGF1R in various cell types.The IGF1R pathway is known to play a crucial role in cell growth, proliferation, and survival, making it a key target in cancer research and therapeutics. Phosphorylation of IGF1R at tyrosine 1161 is particularly important for its activation and downstream signaling, highlighting the significance of studying this specific post-translational modification.
With its high reactivity and specificity for phospho-IGF1R (Y1161), this antibody is essential for investigating the role of IGF1R signaling in cancer development and progression. By understanding the mechanisms underlying IGF1R activation and phosphorylation, researchers can identify potential therapeutic targets for combating IGF1R-driven cancers and developing targeted therapies for patients.
Product Name:
Phospho-IGF1R-Y1161 Rabbit Polyclonal Antibody
SKU:
CABP0367
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around Y1161 of human IGF1R (NP_000866.1).
Sequence:
DIYE T
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:2000
Synonyms:
IGFR; CD221; IGFIR; JTK13; Phospho-IGF1R-Y1161
Positive Sample:
293
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
155kDa
Observed MW:
95kDa
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3480
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from 293 cells, using Phospho-IGF1R-Y1161 Rabbit pAb (CABP0367).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
