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Phospho-Histone H2A (T121) Antibody (PACO03143)

SKU:
PACO03143
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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Phospho-Histone H2A (T121) Antibody (PACO03143)

The Phospho-Histone H2A (T121) Antibody (PACO03143) is a highly specific research tool designed for the study of phosphorylated histone H2A at threonine 121. This antibody, produced in rabbits, is suitable for use in various experimental techniques, including Western blotting and immunofluorescence.Histone H2A is a key component of chromatin structure and plays a vital role in gene regulation and DNA packaging. Phosphorylation of histone H2A at threonine 121 has been linked to various cellular processes, including DNA damage response and chromatin remodeling.

The Phospho-Histone H2A (T121) Antibody enables precise detection and analysis of this phosphorylated form of histone H2A in human samples, making it an essential tool for researchers studying epigenetics, DNA repair mechanisms, and cancer biology.By targeting the phosphorylated form of histone H2A at threonine 121, this antibody provides valuable insights into the regulation of chromatin structure and gene expression, offering new avenues for understanding the molecular mechanisms underlying disease progression and potential therapeutic interventions.

Antibody Name:Phospho-Histone H2A (T121) Antibody
Antibody SKU:PACO03143
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:IHC:1:100-1:300
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from human Histone H2A around the phosphorylation site of T121.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:HIST1H2AG; H2AFP; HIST1H2AI; H2AFC; HIST1H2AK; H2AFD; HIST1H2AL; H2AFI; HIST1H2AM; H2AFN; Histone H2A type 1; H2A.1; Histone H2A/p; HIST1H2AB; H2AFM; HIST1H2AE; H2AFA; Histone H2A type 1-B/E; Histone H2A.2; Histone H2A/a; Histone H2A/m; HIS
UniProt Protein Function:H2A.1: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2A family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: nuclear chromatin; nucleus

Molecular Function:DNA binding; enzyme binding; protein binding

Biological Process: chromatin silencing

NCBI Summary:Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]
UniProt Code:P0C0S8
NCBI GenInfo Identifier:83288406
NCBI Gene ID:8969
NCBI Accession:P0C0S8.2
UniProt Secondary Accession:P0C0S8,P02261, Q2M1R2, Q76PA6,
UniProt Related Accession:P0C0S8
Molecular Weight:14kDa
NCBI Full Name:Histone H2A type 1
NCBI Synonym Full Names:histone cluster 1 H2A family member g
NCBI Official Symbol:HIST1H2AG  
NCBI Official Synonym Symbols:H2AG; H2A/p; H2AFP; H2A.1b; pH2A/f  
NCBI Protein Information:histone H2A type 1
UniProt Protein Name:Histone H2A type 1
UniProt Synonym Protein Names:Histone H2A/p
UniProt Gene Name:HIST1H2AG  

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