The Phospho-Histone H1 (Thr17) Antibody (PAC00168) is a valuable tool for researchers studying histone modifications and their impact on gene expression and cellular processes. This antibody specifically recognizes phosphorylation of Histone H1 at threonine 17, a crucial post-translational modification involved in chromatin condensation and gene regulation.Raised in rabbits, this polyclonal antibody is highly reactive with human samples and has been validated for use in Western blot applications. By targeting the phosphorylated form of Histone H1, researchers can gain insights into the role of this modification in various cellular processes, including DNA replication, transcription, and epigenetic regulation.Histone modifications, such as phosphorylation of Histone H1 at Thr17, play a key role in the dynamic regulation of chromatin structure and gene expression.
Dysregulation of these modifications has been implicated in various diseases, including cancer, making the Phospho-Histone H1 (Thr17) Antibody a valuable tool for studying the molecular mechanisms underlying disease pathology.Overall, the Phospho-Histone H1 (Thr17) Antibody is an essential reagent for researchers interested in exploring the impact of histone modifications on gene expression, chromatin structure, and disease development. Its high reactivity and specificity make it an ideal choice for studies in the fields of epigenetics, cancer research, and molecular biology.
Antibody Name:
Phospho-Histone H1 (Thr17) Antibody
Antibody SKU:
PACO00168
Size:
50ug
Host Species:
Rabbit
Tested Applications:
WB
Recommended Dilutions:
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthetic Peptide
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
H1F1: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 6p21.3Cellular Component: nuclear chromatin; nucleosomeMolecular Function: chromatin DNA binding; protein bindingBiological Process: nucleosome assembly; spermatogenesis
UniProt Protein Details:
NCBI Summary:
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
