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Phospho-Histone H1 (T17) Antibody (PACO02807)

SKU:
PACO02807
Product Type:
Antibody
Reactivity:
Human
Mouse
NHP - Monkey
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

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Phospho-Histone H1 (T17) Antibody (PACO02807)

The Phospho-Histone H1 (T17) Antibody (PAC002807) is a valuable tool for researchers studying the phosphorylation of Histone H1 at threonine 17, a key post-translational modification involved in chromatin remodeling and gene expression regulation. This polyclonal antibody, raised in rabbits, exhibits high specificity and sensitivity for detecting phosphorylated Histone H1 (T17) in human samples, making it ideal for use in Western blot applications.Histone H1 is a linker histone that plays a crucial role in organizing chromatin structure and gene regulation. Phosphorylation of Histone H1 at threonine 17 is known to be involved in the regulation of gene transcription, cell cycle progression, and DNA repair processes.

By targeting this specific phosphorylation site, researchers can gain valuable insights into the mechanisms underlying these biological processes.The Phospho-Histone H1 (T17) Antibody is a valuable tool for studies in epigenetics, cancer research, and developmental biology. Understanding the role of Histone H1 phosphorylation at threonine 17 can provide important information about gene expression regulation and chromatin dynamics, offering potential insights into the development of novel therapeutic strategies for various diseases.

Antibody Name:Phospho-Histone H1 (T17) Antibody
Antibody SKU:PACO02807
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Monkey
Immunogen:synthesized peptide derived from human Histone H1 around the phosphorylation site of T17.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:HIST1H1B; H1F5; Histone H1.5; Histone H1a; Histone H1b; Histone H1s-3; HIST1H1D; H1F3; Histone H1.3; Histone H1c; Histone H1s-2; HIST1H1E; H1F4; Histone H1.4; Histone H1b; Histone H1s-4
UniProt Protein Function:H1B: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: nuclear chromatin; nuclear heterochromatin; nucleosome

Molecular Function:chromatin DNA binding; histone deacetylase binding

Biological Process: establishment and/or maintenance of chromatin architecture; negative regulation of transcription from RNA polymerase II promoter; nucleosome assembly; positive regulation of cell growth; positive regulation of histone H3-K9 methylation; protein stabilization

NCBI Summary:Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
UniProt Code:P16401
NCBI GenInfo Identifier:19856407
NCBI Gene ID:3009
NCBI Accession:P16401.3
UniProt Secondary Accession:P16401,Q14529, Q3MJ42,
UniProt Related Accession:P16401
Molecular Weight:22,580 Da
NCBI Full Name:Histone H1.5
NCBI Synonym Full Names:histone cluster 1, H1b
NCBI Official Symbol:HIST1H1B  
NCBI Official Synonym Symbols:H1; H1B; H1.5; H1F5; H1s-3  
NCBI Protein Information:histone H1.5
UniProt Protein Name:Histone H1.5
UniProt Synonym Protein Names:Histone H1a; Histone H1b; Histone H1s-3
Protein Family:Histone
UniProt Gene Name:HIST1H1B  
UniProt Entry Name:H15_HUMAN

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