The Phospho-Histone H1 (Ser1) Antibody (PAC00166) is a crucial tool for researchers studying post-translational modifications of histone proteins. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it perfect for examining the phosphorylation of Histone H1 at Serine 1.Histone H1 is a key component of chromatin structure, playing a role in gene regulation and DNA packaging. Phosphorylation of Histone H1 at Serine 1 has been linked to various cellular processes, including transcriptional regulation and cell cycle progression. The Phospho-Histone H1 (Ser1) Antibody allows for the detection and analysis of these important modifications, providing valuable insights into epigenetic regulation.
Researchers in the fields of molecular biology, epigenetics, and cancer biology can benefit from using this antibody in techniques such as Western blotting and immunofluorescence. By studying the phosphorylation of Histone H1 at Serine 1, researchers can further understand the intricate mechanisms of gene expression and chromatin dynamics, leading to potential advancements in cancer therapy and other disease treatments. Invest in the Phospho-Histone H1 (Ser1) Antibody for precise and reliable detection of this critical histone modification.
Antibody Name:
Phospho-Histone H1 (Ser1) Antibody
Antibody SKU:
PACO00166
Size:
50ug
Host Species:
Rabbit
Tested Applications:
WB
Recommended Dilutions:
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthetic Peptide
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
H1F1: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 6p21.3Cellular Component: nuclear chromatin; nucleosomeMolecular Function: chromatin DNA binding; protein bindingBiological Process: nucleosome assembly; spermatogenesis
UniProt Protein Details:
NCBI Summary:
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
