The Phospho-HDAC8 (S39) Polyclonal Antibody (CABP0360) is a valuable tool for researchers studying the phosphorylation of HDAC8, a histone deacetylase enzyme involved in epigenetic regulation. This antibody, raised in rabbits, is highly specific and sensitive for detecting phosphorylation at serine 39 in HDAC8 protein samples from human origin. It has been validated for use in Western blot applications, allowing for the precise detection and analysis of phosphorylated HDAC8 in various cell types.HDAC8 is known to play a crucial role in gene expression regulation, DNA repair, and cell cycle progression. Phosphorylation of HDAC8 at serine 39 has been linked to changes in its enzymatic activity, impacting chromatin remodeling and gene transcription.
This antibody enables researchers to explore the functional implications of HDAC8 phosphorylation and its effects on cellular processes such as proliferation, differentiation, and apoptosis.The ability to study the phosphorylation status of HDAC8 with precision opens up new avenues for investigating its role in cancer progression, neurodegenerative diseases, and other pathological conditions. By understanding how phosphorylation affects HDAC8 function, researchers can uncover potential therapeutic targets for the development of novel treatments aimed at modulating epigenetic regulation in disease states.
Product Name:
Phospho-HDAC8-S39 Rabbit Polyclonal Antibody
SKU:
CABP0360
Size:
100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A phospho specific peptide corresponding to residues surrounding S39 of human HDAC8
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
55869
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
