Phospho-HDAC4-S246/HDAC5-S259/HDAC9-S220 Rabbit Polyclonal Antibody (CABP0280)
- SKU:
- CABP0280
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
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Description
Product Name: | Phospho-HDAC4-S246/HDAC5-S259/HDAC9-S220 Rabbit Polyclonal Antibody |
SKU: | CABP0280 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A phospho specific peptide corresponding to residues surrounding S246 of human HDAC4 |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | HDAC4/HDAC5/HDAC9; Phospho-HDAC4-S246/HDAC5-S259/HDAC9-S220 |
Positive Sample: | 293,293+EGF |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, histone deacetylase complex, nuclear speck, nucleoplasm, nucleus |
Calculated MW: | 57-65kDa/97-122kDa |
Observed MW: | 125kDa/140kDa |
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
Purification Method: | Affinity purification |
Gene ID: | 9759/10014/9734 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |