Anti-Phospho-GYS1-S641 Antibody (CABP1129)
- SKU:
- CABP1129
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Metabolism
Description
Anti-Phospho-GYS1-S641 Antibody (CABP1129)
The Phospho-GYS1 (S641) Rabbit Monoclonal Antibody (CABP1129) is a valuable tool for researchers studying glycogen synthase 1 (GYS1) phosphorylation at serine 641. This antibody is specifically designed for use in Western blot applications and is highly reactive with samples from various species, including human, mouse, and rat.GYS1 is a key enzyme involved in glycogen synthesis, which plays a critical role in regulating energy storage and metabolism. Phosphorylation of GYS1 at serine 641 is known to modulate its activity, impacting glycogen synthesis and glucose homeostasis. Research on this post-translational modification of GYS1 is important for understanding its regulatory mechanisms in metabolic diseases, such as diabetes and glycogen storage disorders.
By targeting the phosphorylated form of GYS1, the CABP1129 antibody allows for accurate detection and quantification of this specific modification, enabling detailed analysis of GYS1 signaling pathways in various cell types and tissues. It is a valuable tool for studies in metabolism, diabetes, and other related fields, providing insights into the molecular mechanisms underlying these complex diseases.
| Antibody Name: | Anti-Phospho-GYS1-S641 Antibody |
| Antibody SKU: | CABP1129 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S641 of human GYS1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa+CIP, HeLa |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S641 of human GYS1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2997 |
| Uniprot: | P13807 |
| Cellular Location: | |
| Calculated MW: | 85kDa |
| Observed MW: | 85KDa |
 | Western blot - Phospho-GYS1-S641 Rabbit mAb (CABP1129) |
| Synonyms: | GSY, GYS |
| Background: | The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1, 4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] |
| UniProt Protein Function: | GYS1: muscle glycogen synthase 1. Transfers glucosyl residue from UDP-glucose to glycogen. Regulated allosterically by glucose-6-phosphate, and by PKA-mediated phosphorylation. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: membrane; cytoplasm; inclusion body; cytosol Molecular Function:protein binding; glycogen (starch) synthase activity; protein kinase binding; glucose binding Biological Process: glycogen biosynthetic process; heart development; carbohydrate metabolic process; glucose metabolic process; pathogenesis Disease: Glycogen Storage Disease 0, Muscle |
| NCBI Summary: | The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] |
| UniProt Code: | P13807 |
| NCBI GenInfo Identifier: | 1351366 |
| NCBI Gene ID: | 2997 |
| NCBI Accession: | P13807.2 |
| UniProt Secondary Accession: | P13807,Q9BTT9, |
| UniProt Related Accession: | P13807 |
| Molecular Weight: | 737 |
| NCBI Full Name: | Glycogen |
| NCBI Synonym Full Names: | glycogen synthase 1 (muscle) |
| NCBI Official Symbol: | GYS1Â Â |
| NCBI Official Synonym Symbols: | GSY; GYSÂ Â |
| NCBI Protein Information: | glycogen [starch] synthase, muscle; glycogen [starch] synthase, muscle |
| UniProt Protein Name: | Glycogen [starch] synthase, muscle |
| Protein Family: | Glycogen [starch] synthase |
| UniProt Gene Name: | GYS1Â Â |
| UniProt Entry Name: | GYS1_HUMAN |
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