The Phospho-GYS1 (S641) Polyclonal Antibody (CABP0877) is a valuable tool for researchers studying glycogen synthase 1 (GYS1) phosphorylation at serine 641. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the phosphorylated form of GYS1, this antibody enables the detection and analysis of GYS1 activation in various cell types, making it an excellent choice for studies in metabolism and cellular signaling pathways.GYS1 is a key enzyme involved in glycogen synthesis and glucose metabolism, with phosphorylation at serine 641 playing a role in regulating its activity. Dysregulation of GYS1 phosphorylation has been linked to metabolic disorders, such as diabetes and obesity, making it a promising target for therapeutic interventions.
Understanding the mechanisms of GYS1 activation can provide valuable insights into metabolic diseases and potential treatment strategies aimed at restoring glucose homeostasis.In conclusion, the Phospho-GYS1 (S641) Polyclonal Antibody (CABP0877) is an essential tool for researchers investigating the role of GYS1 phosphorylation in cellular metabolism and disease. Its high specificity and sensitivity make it a reliable choice for studying the intricate regulatory mechanisms of GYS1 activation, paving the way for advancements in metabolic research and therapeutic development.
Product Name:
Phospho-GYS1-S641 Rabbit Polyclonal Antibody
SKU:
CABP0877
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around S641 of human Glycogen synthase 1 (GYS1) (NP_002094.2).
Sequence:
PASV P
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:2000
Synonyms:
GSY; GYS; Phospho-GYS1-S641
Positive Sample:
293T,NIH/3T3,C6
Conjugate:
Unconjugated
Cellular Localization:
cytoplasm, cytosol
Calculated MW:
84kDa
Observed MW:
100kDa
The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2997
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Phospho-GYS1-S641 Rabbit pAb (CABP0877) at 1:1000 dilution.NIH/3T3 cells and C6 cells were treated by CIP(20uL/400ul) at 37℃ for 1 hour.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
